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However, O2- can oxidize phospholipids on the cell membrane to produce peroxides such as malondialdehyde (MDA) and ketone groups containing aldehyde groups to destroy the cell membrane structure (Tao et al., 2024), thus causing a series of diseases (He et al., 2024a)

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As a result of a new awareness of this risk, the monograph on Products of fermentation (1,468) of the European Pharmacopoeia was also amended in March 2018