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It was proved that combined supplementation of CoQ10, vitamin D, alpha-lipoic acid, magnesium, and tryptophan causes a significant reduction of pain after one month of treatment and noticeable improvement in QoL [47]

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Overall, Trp metabolism influences the functional spectrum of macrophages through two intertwined pathways, namely the “stress response induced by Trp depletion” and the “AhR signaling mediated by Kyn/indole derivatives.” The overall outcome is often manifested as restriction of pro-inflammatory programs and support of immunoregulatory/tolerance-related phenotypes, although this effect is condition-dependent and influenced by ligand source (host or microbial), inflammatory stage, and the tissue microenvironment