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However, a recent nonclinical experiment demonstrated that diazepam, zolpidem, and low-dose alprazolam induced a depression-like phenotype in rodents, while a high dose of alprazolam induced an antidepressant-like response, 89 suggesting that alprazolam has specialized effects in its high-dose range that do not generalize to other benzodiazepine-site PAMs
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Indeed, cytosolic GSH is required for the redox regulation of Nonexpressor of Pathogenesis-Related genes 1 (NPR1) to generate its monomeric form, allowing its nuclear translocation and transcription of pathogenesis related genes [93]
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