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The clinical trade-off: Zepbound (tirzepatide 15 mg): Average weight loss 20.9% at 72 weeks (Jastreboff et al., NEJM 2022) Wegovy (semaglutide 2.4 mg): Average weight loss 14.9% at 68 weeks (Wilding et al., NEJM 2021) Zepbound produces about 6 percentage points more weight loss in head-to-head comparison, but Wegovy still delivers clinically significant results for most patients
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