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A potent peptide in the wrong formulation will not reach its target

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We also took into consideration that whole blood (mainly erythrocytes) contributed up to 10% of whole body GSH synthesis in humans and that extracellular concentrations of GSH were relatively low (e.g., 2 μ mol/L in plasma), due to the cysteine residue of GSH, which was readily oxidized in a nonenzymatic way to GSSG by electrophilic substances (e.g., free radicals and reactive oxygen/nitrogen species)