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The main mechanisms of MTX toxicity in experimental disease models of... | Download Scientific Diagram
Caspase-3, as a principal executioner caspase, cleaves multiple cellular substrates, resulting in hallmark apoptotic changes such as DNA fragmentation, chromatin condensation, and cellular shrinkage
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These proinflammatory molecules also induce the above lesions through the nuclear factor-κB (NF-κB), Janus kinase/signal transducers and activators of transcription (JAK/STAT), and TGF-β/Smad signaling pathways[99-101]
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