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The mitochondrial membrane potential of protein is related to mPTP, In the early stage of apoptosis, mPTP can allow molecules with relative molecular weight less than 1.5 × 10 3 kDa to pass through, which leads to the decrease of mitochondrial membrane potential, the increase of mitochondrial membrane permeability and the release of pro-apoptotic proteins, which leads to apoptosis (Fall and Bennett, 1999)
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