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Over the 16-week treatment period, the decline in ALS Functional Rating Scale–Revised (ALSFRS-R) scores was smaller in the MeCbl group than in the placebo group, and adverse event rates were similar between groups.6 6.2 Peripheral Neuropathy and Axonal Degeneration A phase I/II open-label trial evaluated 14 patients with chronic immune-mediated or hereditary neuropathies and electrodiagnostic evidence of axonal degeneration

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In animal models, mice with decreased NNMT levels exhibited heightened energy expenditures compared to control mice of similar weights (Kraus et al., 2014)