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A: A vitamin B shot, most commonly referring to a B12 injection, is an intramuscular injection that delivers a concentrated dose of B vitamins directly into your bloodstream, bypassing the digestive system

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In these individuals it would appear that whilst they were able to exist as relatively healthy individuals, often not knowing that they had methylation associated mutations, some initiating factor such as a prolonged infection, combined with low vitamin D levels resulted in gradual loss of their vitamin B12 supplies leading to the CFS symptomatology being apparent, and the subsequent discovery of their methylation status