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rhamnosus not only induce an anti-inflammatory phenotype in M2 macrophages but also make M1 macrophages convert to a less inflammatory phenotype by suppressing the immune activation markers like CD14, CD80, and HLA-DR also decrease pro-inflammatory cytokines like IL-12, IL-1β, and TNF-α and increase anti-inflammatory cytokines like IL-10 and TGF-β in SLE patient macrophages ( Figure 2 ) (101)

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In vitro evaluation of curcumin’s antisickling activity and in silico analysis of curcuminoids and their ADMET properties