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DPP1’s exclusion domain serves as its unique functional component, precisely regulating exopeptidase activity and ensuring specific N-terminal protein substrate processing by restricting substrate entry patterns ( Regarding cellular distribution, while DPP1 expression occurs across various cell types, expression levels peak in myeloid cells, particularly neutrophils, mast cells, and monocytes ( 2.2 Biological functions and pathological significance of NSPs The NSP family encompasses three key proteases: NE, PR3, and CatG, which serve central roles in neutrophil-mediated innate immunity and inflammatory regulation