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RCSB PDB - 2I3Y: Crystal structure of human glutathione peroxidase 5
System X(c) (−)/GSH/GPX4 axis: an important antioxidant system for the ferroptosis in drug-resistant solid tumor therapy
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As mentioned above, another central player in these redox systems is thioredoxin, which is reduced by NADPH to induce the transfer of electrons for use in DNA synthesis, signal transduction and redox regulation
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