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It is generally harmless, does not reduce the effectiveness of the treatment, and usually settles on its own within 24 to 72 hours
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In addition, our in vitro studies indicate a novel mechanism, that is GSTP can be phosphorylated at Ser184 and enter the nucleus under LPS stimulation, and GSTP interacted with HMGB1 to inhibit cPKC-mediated phosphorylation of HMGB1 and association between HMGB1 and CRM1 in the nucleus
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